Genzyme Osteopenia/Osteoporosis Study

Inclusion Criteria: * Patients \> or equal to18 years and able to provide written consent. * Patients who have had a bone density test demonstrating T-score \<-1.0 on a DEXA scan within the past year or those who are prospectively referred for DEXA scan and who are later identified by their physician to have a DEXA T-score \< -1.0. Exclusion Criteria: * Subject unable to read and sign consent form. * Terminally ill subjects or subjects with serious co-morbidities (malignancy), which would limit the ability of the patient to participate in the study. * Subjects with the following disorders or exposures * Underlying skeletal dysplasia * An endocrinologic/metabolic disease known to cause bone demineralization: including parathyroid dysfunction, hyperthyroidism, Cushing syndrome, hypogonadism, panhypopituitarism * Cystic Fibrosis * Exposure to medications that are known to cause low BMD including chemotherapy within past 2 years, chronic corticosteroid or phenytoin use within past 2 years * Radiation exposure within the past 5 years * Vitamin D deficiency is not an exclusion criteria as this is highly prevalent in the adult population under investigation as well as in patients with Gaucher disease. (9, 10) * Subjects previously diagnosed with Gaucher Disease