A Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A in Patients With Overactive Bladder (OAB)

Inclusion Criteria: 1. All patients should provided written informed consent. 2. Patients with idiopathic or neurogenic overactive bladder with symptoms of episodes of urgency, incontinence, micturition and nocturia,( maintaining spontaneous voiding ). 3. Patients must experienced 3 or more urgency UI episodes in a 3-day period and an average of 8 or moremicturitions per day. 4. Patients were inadequately treated with prior anticholinergic therapy due to inadequate efficacy or intolerable side effects. 5. Anticholinergic use was not permitted within 7 days of screening or patients treated with anticholinergics at baseline continued at a stable dose throughout the study. Exclusion Criteria: 1. Patients with difficulty urinating have a PVR of 50 ml or more. 2. Patients requiring indwelling catheter or clean intermittent catheterization (CIC). 3. Female patients who is pregnant, lactating, or with child-bearing potential without contraception. 4. People who are allergic to study drugs or its ingredients or allergic should be excluded. 5. Current severe cardiovascular disease ongoing clinical instability. 6. Renal insufficiency and serum creatinine greater than 1.5 times the upper limit of normal. 7. Liver diseases, ALT or AST greater than 2 times the upper limit of normal. 8. Alcohol or drug abusers. 9. Have participated in the clinical trials of other drugs within a month. 10. Any previous botulinum toxin therapy for a urologic condition within 6 months. 11. Urinary tract infection (① patients with symptoms of fever, pyuria, urinary frequency, urgency or dysuria etc.; ② positive urine culture ( bacterial colony counts \> 10\^5 cfu/ml) or urine WBC\> 10/ HPF; meet both of ① and ② or any one can be diagnosed as a urinary tract infection). 12. Patients accompany of bladder stones, ureteral stones or urethral; or lithotripsy performed within 3 months. 13. Patients of bladder or prostate cancer. 14. Patients with diabetes. 15. Patients with aminoglycoside antibiotics or neuromuscular junction function drugs within one week. 16. Any medical condition that may lead the subject to increased risk with exposure to Botulinum Toxin Type A, including myasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis, or any other disorder that might have interfered with neuromuscular function. 17. Patients with bleeding tendency. 18. Patients have used anticoagulant agents within one week before the first use of study drug. 19. Investigator's opinion that the subject has a concurrent condition(s) that may put the subject at significant risk, may confound the study results, or may interfere significantly with the conduct of the study.