The present study is a pilot single-blind randomized controlled therapy study. Its aim is to assess the efficacy of an emotion-focussed form of Cognitive behavior Therapy that focusses on emotional processes that are involved in the formation and maintenance of delusions such as emotional stability, emotion regulation and self-esteem.
Cognitive Behavior Therapy for psychosis (CBTp) is an effective treatment for patients with psychosis. Several meta-analyses showed an effect of CBTp in addition to antipsychotic treatment of small to medium effect size with regard to positive symptoms, general psychopathology and depression. Nevertheless, present research suggests that are especially emotional processes are closely related to positive symptoms and delusions, such as negative emotions, low self-esteem, depression and anxiety, whereas present interventions of CBTp focus often especially on cognitive interventions in order to change delusions as well as more cognitive risk factors for delusions such as reasoning biases and a dysfunctional causal attribution style. Thus, the aim of the present single-blind randomized-controlled pilot therapy study was to assess the efficacy of a new form of emotion-focussed Cognitive behavior therapy for psychosis with regard to change in positive symptoms and delusions in comparison to standard treatment. The main hypotheses are: \- Efficacy of CBT-E: patients with schizophrenia who receive CBT-E show a more pronounced reduction of delusions (primary outcome), as well as a more pronounced reduction of positive symptoms, depression and general psychopathology, a stronger improvement in general and social functioning and will receive lower doses of antipsychotic medication (secondary outcomes) at post-treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
64
Patients receive 25 sessions of individual emotion-focused Cognitive Behavior Therapy based on a manual. Interventions aim on patients' mood by implementing positive activities in their daily routine. Further, patients train to reduce worrying behavior. Social contacts are fostered as well. Later, patients are informed on emotions and train emotion regulation strategies. Finally, the focus of CBT-E is on self-acceptance.Patients receive psychoeducation on self-acceptance and learn strategies in order to reduce negative self-schema and foster positive self-schema.
Patients receive standardized treatment. After a waiting period of six month, patients receive CBT-E
University of Marburg, Faculty of Clinical Psychology and Psychotherapy
Marburg, Hesse, Germany
University of Hamburg, Faculty of Clinical Psychology and Psychotherapy
Hamburg, Germany
Change in Psychotic Rating Scale (PSYRATS) delusions scale
Assessment of delusion frequency, delusion distress, conviction and loss of quality of life
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Positive and Negative Syndrome Scale (PANSS)
Assessment of positive, negative and general symptoms of schizophrenia
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Calgary Depression Rating Scale for Schizophrenia (CDSS)
Assessment of depressive symptoms in patients with schizophrenia
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Role Functioning Scale (RFS)
Assessment of social functioning
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Paranoia Checklist (PCL)
Assessment of self-reported paranoid delusion frequency, distress and conviction
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Beck Depression Inventory-II
Assessment of self-reported depressive symptoms
Time frame: Change between assessment pre-therapy and assessment after six month of therapy
Change in Peters et al. Delusions Inventory
Assessment of self-rated delusion frequency, delusional distress and delusional
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Time frame: Change between assessment pre-therapy and assessment after six month of therapy