Short sleep duration has been associated with increased risk of weight gain and development of non-communicable diseases. Sleep deprivation studies have suggested the link between restricted sleep and risk of adiposity and cardiometabolic dysregulation may be causal. However, the severity and acuteness of sleep restriction schedules in laboratory-based studies could hinder the ecological validity of the findings. The pragmatic way forward is to assess how improved sleep in habitually short sleepers impacts the aforementioned outcomes. This study assesses the feasibility of lengthening sleep in short sleepers, as well as how improved sleep duration and/or quality impact metabolic health, body composition, energy balance and cardiovascular risk.
Research Questions * Is it feasible to improve sleep duration and quality in habitually short sleepers under free-living conditions? * What are the effects of improved sleep duration and quality on body composition, energy balance, dietary intake, and cardio-metabolic risk factors? Hypothesis \- Improved sleep duration and/or quality in habitually short sleepers will result in improved energy balance, diet quality, body composition, and cardio-metabolic risk profile. Aims * To assess the feasibility of improving sleep duration and/or quality in habitually short sleepers using behavioural approaches and public health messages targeting sleep hygiene. * To identify how improved sleep duration and/or quality affect energy balance, diet quality, body composition, and cardio-metabolic risk profile. Objectives 1. To develop a sleep extension strategy using behaviour change techniques (BCTs) targeting sleep hygiene. 2. To recruit healthy adults who are habitually short sleepers and randomise eligible participants to an intervention and control group. 3. To assess the feasibility and effectiveness of the intervention. 4. To measure energy balance, diet quality, body composition and cardio-metabolic risk factors pre- and post-treatment in the intervention and control groups. 5. To assess whether the intervention had an effect on the aforementioned parameters by comparing the intervention endpoints to control as well as baseline measures. 6. To run the statistical analysis both on an intention-to-treat basis as well as per-protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
43
Behaviour change techniques targeting sleep hygiene
Diabetes & Nutritional Sciences Division, King's College London
London, United Kingdom
Sleep Duration
Wrist Actigraphy
Time frame: baseline
Sleep Duration
Wrist Actigraphy
Time frame: week 4
Sleep Quality
Wrist Actigraphy
Time frame: baseline
Sleep Quality
Wrist Actigraphy
Time frame: week 4
BMI
Time frame: baseline
BMI
Time frame: day 28
Body fat percentage
Time frame: baseline
Body fat percentage
Time frame: day 28
Blood pressure
Time frame: baseline
Blood pressure
Time frame: day 28
Fasting blood glucose
Time frame: baseline
Fasting blood glucose
Time frame: day 28
Fasting total cholesterol
Time frame: baseline
Fasting HDL cholesterol
Time frame: baseline
Fasting LDL cholesterol
Time frame: baseline
Fasting triglycerides
Time frame: baseline
Fasting total cholesterol
Time frame: day 28
Fasting HDL cholesterol
Time frame: day 28
Fasting LDL cholesterol
Time frame: day 28
Fasting triglycerides
Time frame: day 28
plasma leptin
Time frame: baseline
plasma leptin
Time frame: day 28
plasma ghrelin
Time frame: baseline
plasma ghrelin
Time frame: day 28
plasma insulin
Time frame: baseline
plasma insulin
Time frame: day 28
plasma cortisol
Time frame: baseline
plasma cortisol
Time frame: day 28
Homeostasis model assessment estimated insulin resistance (HOMA-IR)
Time frame: baseline
Homeostasis model assessment estimated insulin resistance (HOMA-IR)
Time frame: day 28
Waist circumference
Time frame: baseline
Waist circumference
Time frame: day 28
Hip circumference
Time frame: baseline
Hip circumference
Time frame: day 28
Lean body mass
Time frame: baseline
Lean body mass
Time frame: day 28
Digital volume pulse - Stiffness Index (SI)
Time frame: baseline
Digital volume pulse - Stiffness Index (SI)
Time frame: day 28
Digital volume pulse - Reflection Index (RI)
Time frame: baseline
Digital volume pulse - Reflection Index (RI)
Time frame: day 28
Mnemonic Similarity Test (MST)
Time frame: baseline
Mnemonic Similarity Test (MST)
Time frame: day 28
Dietary Intake (7-day food diary)
Time frame: baseline
Dietary Intake (7-day food diary)
Time frame: week 4
Resting Metabolic Rate (RMR)
Time frame: baseline
Resting Metabolic Rate (RMR)
Time frame: day 28
Total Energy Expenditure (TEE)
Time frame: baseline
Total Energy Expenditure (TEE)
Time frame: day 21-23
Urinary 6-sulphatoxymelatonin
Analysed from spot urine sample
Time frame: baseline
Urinary 6-sulphatoxymelatonin
Analysed from spot urine sample
Time frame: day 28
Recent Physical Activity Questionnaire (RPAQ)
Time frame: baseline
Recent Physical Activity Questionnaire (RPAQ)
Time frame: day 28
Sleep Hygiene Index (SHI)
Time frame: baseline
Sleep Hygiene Index (SHI)
Time frame: day 28
Eating Choices Index (ECI)
Time frame: baseline
Eating Choices Index (ECI)
Time frame: day 28
Pittsburgh Sleep Quality Index (PSQI)
Time frame: baseline
Pittsburgh Sleep Quality Index (PSQI)
Time frame: day 28
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