To evaluate the efficacy and safety of pegteograstim on chemotherapy-induced neutropenia in children with solid tumors
Children with solid tumor experience neutropenia after cytotoxic chemotherapy, and they usually receive granulocyte colony-stimulating factor (G-CSF) to stimulate neutrophil recovery. However it needs daily injection of G-CSF. Pegteograstim is a new formulation of PEGylated recombinant human G-CSF analogue pegfilgrastim. In this study, investigators aimed to evaluate the efficacy and safety of pegteograstim on chemotherapy-induced neutropenia in children with solid tumors.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
34
Samsung Medical Center
Seoul, South Korea
RECRUITINGRate of adverse events
Time frame: Up to 3 weeks after the injection of pegteograsim
Duration of neutropenia (absolute neutrophil count (ANC) < 500/uL)
Time frame: Up to 6 weeks
Duration of severe neutropenia (ANC < 100/uL)
Time frame: Up to 6 weeks
Lowest value of ANC
Time frame: Up to 6 weeks
Days with neutropenic fever
Time frame: Up to 6 weeks
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