Treat-and-extend Regimen of Aflibercept in Diabetic Macular Edema (VIBIM Study)

Inclusion Criteria: 1. Type I or II diabetes older than 18 years old 2. Patients with DME secondary to diabetes mellitus involving the center of the macula (defined as CSMT \>= 300μm measured using OCT) in the study eye. 3. Decreased visual acuity to 20/40 - 20/300 to be primarily the results of DME in the study eye. 4. Willing and able to comply with clinic visits and study-related procedures, and provide a signed informed consent form. Exclusion Criteria: 1. History of vitreoretinal surgery including scleral buckling in the study eye. 2. Laser photocoagulation (panretinal or macular) in the study eye within 90 days of day 1. 3. More than two previous macular laser treatments in the study eye. 4. Previous use of intraocular or periocular corticosteroids in the study eye within 120 days of day 1. 5. Previous treatment with anti-angiogenic drugs in the study eye within 90 days of day 1. 6. Active proliferative diabetic retinopathy in the study eye. 7. History of idiopathic or autoimmune uveitis in the study eye. 8. Cataract surgery within 90 days before day 1 in the study eye. 9. Aphakia in the study eye. 10. Yttrium-aluminium-garnet capsulotomy in the study eye within 30 days before day 1. 11. Vitreomacular traction or epiretinal membrane in the study eye evident biomicroscopically or on OCT that is thought to affect central vision. 12. Current iris neovascularization, vitreous hemorrhage, or tractional retinal detachment in the study eye. 13. Structural damage to the center of the macula in the study eye that is likely to preclude improvement in best-corrected visual acuity (BCVA) following the resolution of macular edema including atrophy of the retinal pigment epithelium, subretinal fibrosis or scar, significant macular ischemia or organized hard exudates. 14. Evidence of infection including infectious blepharitis, keratitis, scleritis, or conjunctivitis in either eye. 15. Uncontrolled glaucoma in the study eye (\>25mmHg) or filtration surgery and/or valve surgery for glaucoma in the past on the study eye. 16. Myopia of a spherical equivalent prior to any possible refractive or cataract surgery of ≥ -8 diopters. 17. Concurrent disease in the study eye, other than DME, that could compromise VA, require medical or surgical intervention during the study period, or could confound interpretation of the results (including retinal vascular occlusion retinal detachment, macular hole, or choroidal neovascularization of any cause). 18. Ocular media of insufficient quality to obtain fundus and OCT images. 19. Current treatment for a serious systemic infection. 20. Administration of systemic anti-angiogenic agents within 180 days before day 1. 21. Uncontrolled diabetes mellitus in the opinion of the investigator (VISTA) or as defined by hemoglobin A1c \>12%. 22. Uncontrolled blood pressure (defined as systolic \>160 mmHg or diastolic \> 95 mmHg while patient is sitting). 23. History of either cerebral vascular accident and/or myocardial infarction within 180 days prior to day 1. 24. Renal failure requiring dialysis or renal transplant. 25. History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug, might affect interpretation of the results of the study, or renders the patient at high risk for treatment complications. 26. Pregnant or breast-feeding women. 27. Sexually active men or women of childbearing potential who are unwilling to practice adequate contraception during the study. 28. Allergy to fluorescein. 29. Patients with hypersensitivity to study drug or excipients. 30. Participation in an investigational study within 30 days prior to screening visit that involved treatment with any drug (excluding vitamins and minerals) or device.