Continuous NMB in PCAS

Chun Song Youn81 enrolled

Overview

The main purpose of this study is to test the hypothesis that continuous NMB could improve outcome in cardiac arrest patients treated with therapeutic hypothermia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Out-of-hospital Cardiac Arrest

Interventions

EsmeronDRUG

Neuromuscular Blockade

SalineDRUG

Normal Saline

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adult (older than 19) 2. OHCA with sustained ROSC 3. Comatose (i.e., not following commands) following ROSC 4. Undergoing targeted temperature management (TTM) 5. Time of enrollment ≤ 6hrs from ROSC Exclusion Criteria: 1. Pre-existing dementia, brain injury, or dependence on others for ADLs (CPC \> 3) 2. Traumatic etiology for cardiac arrest 3. Protected population (pregnant, prisoner)

Locations (1)

Seoul St. Mary's Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Lactate levels 24 hours after initiation of study drug

Time frame: 24 hours

Secondary Outcomes

Lactate change over time

Time frame: 0, 12, 24, 36 hrs

Survival

in-hospital survival

Time frame: Duration of hospitalization, limit 180 days

Good neurological outcome

Modified Rankin Scale

Time frame: Duration of hospitalization, limit 180 days

Length of intensive care unit stay

Time frame: Duration of ICU stay, limit 180 days

Data from ClinicalTrials.gov

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