The objectives of this clinical study are to determine the tolerance of dietary supplement Valedia (blend of plant extracts) through the evaluation of several parameters : * Various blood biological parameters for tolerance (preprandial): blood glucose, insulin, fructosamine, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, oxidized LDL, us-CRP, creatinine, ASAT, ALAT, gGT, phosphatase alcaline, bilirubine, urea. * Urinary parameters: urea, creatinine. * Hemodynamic parameters: heart rate and blood pressure. * Cardiac function: ECG. * Weight.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
Centre d'Investigation Clinique
Clermont-Ferrand, France
Effect on urine urea
Urine urea
Time frame: 10 weeks
Effect on urine creatinine
Urine creatinine
Time frame: 10 weeks
Effect on fasting glycemia
Fasting blood glucose
Time frame: 10 weeks
Effect on insulin
Plasma insulin
Time frame: 10 weeks
Effect on fructosamine
Blood fructosamine
Time frame: 10 weeks
Effect on total cholesterol
Blood total cholesterol
Time frame: 10 weeks
Effect on HDL cholesterol
Blood HDL cholesterol
Time frame: 10 weeks
Effect on LDL cholesterol
Blood LDL cholesterol
Time frame: 10 weeks
Effect on triglycerides
Blood triglycerides
Time frame: 10 weeks
Effect on oxidized LDL cholesterol
Blood oxidized LDL cholesterol
Time frame: 10 weeks
Effect on inflammation
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Blood us-CRP
Time frame: 10 weeks
Effect on AST
Blood AST
Time frame: 10 weeks
Effect on ALT
Blood ALT
Time frame: 10 weeks
Effect on gamma GT
Blood gamma GT
Time frame: 10 weeks
Effect on alkaline phosphatase
Blood phosphatase alkaline
Time frame: 10 weeks
Effect on bilirubin
Blood bilirubin
Time frame: 10 weeks
Effect on cardiac function
ECG
Time frame: 10 weeks
The response during an oral glucide tolerance test after a standardized breakfast
Oral glucose tolerance test (after a standardized breakfast) with glycemia and insulinemia measurements (-10 min, -5 min, +15 min, +30 min, +45 min, +60 min, +90 min, +120 min, arrival at center in fasting state)
Time frame: 10 weeks