Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

N/ACompletedNCT02792010

Hospices Civils de Lyon31 enrolled

Overview

Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Healthy Volunteers

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \<30 * Accepting to participate in the study and signed the written informed consent * Covered by a health insurance system Exclusion Criteria: * Pregnant woman or risk of pregnancy * MRI contraindication * Protected adults * Language barrier * Previous or current hip pain

Outcomes

Primary Outcomes

Quantification of the cartilage signal at T1rho MRI

T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Time frame: Up to one month after inclusion (Visit 1)

Secondary Outcomes

Quantification of the cartilage signal at T1rho MRI

T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

Quantification of the cartilage signal at T2 MRI

T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Time frame: Up to one month after inclusion (Visit 1)

Quantification of the cartilage signal at T2 MRI

T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

Presence of cartilage lesions

Morphological sequence to determine focal lesions

Time frame: Up to one month after inclusion (Visit 1)

Presence of cartilage lesions

Morphological sequence to determine focal lesions

Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes