The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams

University of Bern32 enrolled

Overview

In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Neuroscience of Dreaming, Healthy

Interventions

NaltrexoneDRUG

one week

PlaceboOTHER

one week

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Healthiness * Good capacity of remembering dreams * No opiate consumption Exclusion Criteria: * Simultaneous participation in other studies * Addictive disorder * Abnormal liver function * Abnormal kidney function * Hypersensitivity to active ingredient or pharmaceutical additives * Hereditary galactose intolerance * Lactase deficiency * Glucose-galactose malabsorption * Intake of opioid medication

Locations (1)

University of Bern

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

VAS-difference concerning the emotional valence of dreams

Difference between the mean values of emotional valence of dreams reported in the conditions (Naltrexone, Placebo), as captured in VAS \[visual analog scales\] for every dream

Time frame: 7 days per condition (Naltrexone, Placebo), intermitted by 14 days of washout

Secondary Outcomes

Semiquantitative score of emotional valence of dreams

Based on computational linguistic analysis of the dreams

Time frame: 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout

Qualitative score of emotional valence of dreams

Based on lexical coding of the dreams

Time frame: 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout

Data from ClinicalTrials.gov

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