The Role of CVP and EF in Patients With Cardio-renal Syndromes

Tbilisi State University11 enrolled

Overview

The aim of the study is to explore association between increased central venous pressure, Ejection Fraction and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. The pilot study was set to provide the expected correlation coefficient for a sample size determination of the subsequent study.

OBJECTIVES The aim of the study is to explore association between increased central venous pressure (CVP), Ejection Fraction (EF) and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. BACKGROUND The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. Recent investigations suggest that management of patients based on low-flow theory does not lead to improved outcomes. Relative importance of right heart dysfunction (manifested as increased CVP) has not been evaluated . Precise understanding of bidirectional pathways by which the heart and kidneys influence each other is necessary to define optimal treatment strategies specific to the subtypes, as therapies directed towards one organ system may have beneficial or unfavorable effects on the other. METHODS The study is of non-experimental (observational) type, based on retrospective chart review. The patients' personal identifiers are concealed and an anonymized datasets used (unique code given to each patient, which is kept secure under the control of hospital staff).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure

Interventions

CVP measurementOTHER

CVP measurements had been performed with an electronic pressure transducer in spontaneously breathing non-ventilated patients. Central vein access was established trough the subclavian or internal jugular veins. Mean CVP was recorded for each patient, measured in mmHg.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HF (NYHA class I - IV, with preserved and reduced EF) and reduced GFR (Cardio-Renal Syndromes 1 and 2) Exclusion Criteria: * Independent risk factors for renal impairment (e.g. diabetes, sepsis) * Primary nephropathy or secondary nephropathy due to diseases other than HF

Outcomes

Primary Outcomes

renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)

Estimated Glomerular Filtration Rate has been assessed with the Modification of Diet in Renal Disease formula

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

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