The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
24
Charité Universitätsmedizin Berlin
Berlin, State of Berlin, Germany
GABA concentration assessed by magnetic resonance spectroscopy (MRS) after anodal tDCS adjusted for baseline levels
Investigation whether anodal tDCS leads to a significant reduction of M1-GABA concentration in older adults compared to sham stimulation.
Time frame: assessed immediately before and after a 15-min stimulation time
GABA concentration assessed by MRS before and after cathodal tDCS adjusted for baseline levels
To assess stimulation effects on GABA concentration by magnetic resonance spectroscopy are measured before and after cathodal tDCS.
Time frame: assessed immediately before and after a 15-min stimulation time
Resting-state functional connectivity changes
Functional connectivity as measured by resting-state fMRI during tDCS compared to sham
Time frame: assessed during a 15-min stimulation time
Genotyping of learning related polymorphisms
To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed
Time frame: assessed during baseline screening
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