Intraoperative Placement of Cesium-131 Permanent Interstitial Brachytherapy in Head and Neck Cancer

Inclusion Criteria: * Subjects must have histologically or cytologically confirmed recurrent head and neck cancer. * Based on clinical and radiographic evidence the tumor needs to be deemed resectable preoperatively by the surgeon and when necessary (determined by the surgeon) tumor board review. * Patients must have potentially curable disease * Karnofsky Performance status ≥ 60% (ECOG/Zubrod 0,1,or 2) * Subjects must have normal organ and marrow function as defined below: * Hemoglobin ≥ 7.0 g/dl * Absolute neutrophil count (ANC) \> 500/mcL * Platelet count ≥ 75,000/mcL * Patients with recurrent/previous treated head and neck squamous cell carcinoma that is deemed surgically resectable by the treating physician but at high risk for recurrence due to concerns regarding close and/or margins due to locations on or near critical structures such as internal or common carotid, skull base, deep cervical musculature, and other areas that may limit the possibility of an enbloc resection. This group otherwise would be considered for retreatment with radiation and/or chemoradiation. * Subjects must have the ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients deemed to have un-resectable disease by the treating surgeon or upon tumor board review. * Patients with exposed carotid artery preoperatively requiring sacrifice or bypass intra-operatively * Patients with active pharyngocutaneous fistula * Patients may have had a recent previous hospital admission (within 30 days) or be admitted preoperatively but not for the following conditions * Unstable angina * Congestive heart failure * Severe hypothyroidism TSH \>10 \---- Endocrine consult and intervention may allow participation at the discretion of the principal investigator for a thyroid-stimulating hormone (TSH) \> 10. * Patients deemed to be "High Risk" by pre admission testing (CPM) or by a preoperative risk assessment by the hospitalist for perioperative complications * Subjects with more than one site of distant metastatic disease (beyond the head and neck) as evidenced by computerized tomography (CT) scan or positron emission tomography/CT (PET/CT) or biopsy ---- A subject with a single lung nodule (deemed cancerous by PET/CT or Biopsy) will not be excluded. * Subjects receiving any other investigational agents. * Subjects with untreated brain metastases/central nervous system disease will be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to Cesium 131 or other agents used in this study. * Pregnant or breastfeeding women are excluded from this study because Cesium 131 has the potential for teratogenic or abortifacient effects. Because there is an unknown, but potential risk for adverse events in nursing infants secondary to treatment of the mother with Cesium 131, breastfeeding should be discontinued if the mother is treated with Cesium 131. These potential risks may also apply to other agents used in this study. * Subjects who are HIV-positive will be excluded from the study. HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with Cesium 131. In addition, these subjects are at increased risk of lethal infections when treated with marrow suppressive therapy. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.