Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency

Inclusion Criteria: 1. Aged 18-40 2. Menstrual cycle change more than 7 days at least 2 times,amenorrhea less than 6 months. 3. Sex hormone:bFSH\>10u/L;or E2\>80pg/ml. 4. AMH\<1ng/ml. 5. Informed consent and truthfully answer the question. Exclusion Criteria: 1. Dose not meet the inclusion criteria. 2. Genital tract malformation,congenital germinal aplasia, uterine amenorrhea and so on organic disease. 3. Endocrine diseases such Polycystic ovary syndrome、hyperprolactinemia 、dysfunctional uterine bleeding、low gonadotropin menstrual disorders and hyperthyreosis 4. Autoimmune disease patients:Hashimoto's thyroiditis,SLE,Primary chronic adrenal cortical insufficiency,Asthenic bulbar paralysis,Arthritis deformans,Idiopathic thrombocytopenic purpura, type I diabetes and so on. 5. Someone who have the following gynecological operation history: oophorocystectomy,ovarian drilling,wedgeshaped oophorectomy,adnexectomy,tubal resection,ligation of oviduct,pelvic abscess surgery,uterine arterial embolization. 6. Someone who have used reproductive toxicity drugs: tripterygium wilfordii,tripterygium hypoglaucum hutch,chemotherapeutics and so on. 7. A family history of ovarian failure. 8. Have receive hormone therapy in recent 3 months. 9. Pregnant or lactating women. 10. with serious heart,liver and kidney disease 11. With severe psychiatric disorders . 12. Have participated in other clinical trials in 3 months.