Efficacy and Safety of Grass-SPIRE Registration Study

Inclusion Criteria: * Clinical history of grass pollen-induced allergic rhinitis with or without conjunctivitis for at least 2 years * Score of ≤ 21 on RCAT questionnaire * Rye grass specific IgE of ≥ 0.7 kU/L * Positive skin prick test to Rye grass whole allergen extract Exclusion Criteria: * History or findings of significant disease * Asthma requiring GINA Step 3 or higher treatment * History of severe drug allergy, severe angioedema or systemic allergic reaction * Course of short-duration allergy-specific immunotherapy or more than 3 months treatment with long-duration allergen immunotherapy within 5 years * Contraindications for administration of epinephrine