A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)

Inclusion Criteria: * Male or female, at least 12 years of age * Diagnosis of PH1, confirmed by genotyping * 24-hour urine oxalate excretion as defined in the protocol * eGFR ≥ 40 mL/min normalized to 1.73 m2 BSA * Written informed consent for adults (≥18 years old, or per local regulatory requirement); written informed assent for adolescents (12 to \<18 years old, or per local regulatory requirement) Exclusion Criteria: * Prior renal and/or hepatic transplantation * Participation in any clinical study involving administration of any investigational drug within the 30 days before enrollment * Pregnancy or lactation at the time of screening or enrollment * Women of child-bearing potential must have a negative pregnancy test, cannot be breastfeeding and must be willing to use contraception * Patients with a known history of human immunodeficiency virus (HIV) or active infection with hepatitis B virus or hepatitis C virus * Moderate to severe liver impairment * Liver function test abnormalities: alanine transaminases (ALT) and/or aspartate transaminases (AST) \> 2 times upper limit of normal (ULN) * History of severe reaction to a liposomal product or a known hypersensitivity to lipid products. * Unable to collect required study samples or follow study procedures * No clinically significant health concerns