Personalised Therapy for Metastatic ADPC Determined by Genetic Testing and Avatar Model Generation

Inclusion Criteria: * Histologically or cytologically confirmed diagnosis of adenocarcinoma of the pancreas. * ECOG performance status 0 or 1 * Age ≥ 18 years old. * Willingness of male and female subjects, who are not surgically sterile or postmenopausal, to use reliable methods of birth control (oral contraceptives, intrauterine devices, or barrier methods used with a spermicide) for the duration of the study. * One or more sites of metastasis with one of the susceptible of biopsy. * Measurable or evaluable disease * No prior treatment with radiotherapy, surgery, chemotherapy or investigational treatment for the metastatic disease or no more than the three cycles of first line chemotherapy. Palliative radiotherapy for bone metastasis is allowed. Adjuvant or neoadjuvant radiotherapy or chemotherapy are allowed if they finished more that 6 months ago and the patient has no remaining toxicities. * Bone marrow function as follows, no more than 14 days prior to randomisation: ANC \> 1,500 cells/mm3 Platelets \> 100,000 cells/mm3 Hemoglobin ≥9 g/dl * Adequate liver, renal and bone marrow functions. * AST (SGOT), ALT (SGPT) ≤ 2.5 × ULN and ≤ 5 x ULN if liver metastases. * Bilirubin ≤ 1,5 x ULN * Albumin total ≥ 0,75 ULN * Creatinine ≤ 1,5 x ULN * Ability to sign informed consent * Patients will be allowed to be randomised just once. Exclusion Criteria: * Brain metastases, unless they have been previously treated and stable for 3 months at least (defined as no oedema, no need of steroids and stable disease in two CT scans separated by a minimum of 4 weeks). * Locally advanced disease. * Malignancies other than pancreatic cancer diagnosed within 5 years prior to randomization, except for adequately treated carcinoma in situ or basal or squamous cell skin cancer. * Bacterial, viral or fungal active infection that require systemic treatment. * Any contraindication for tumor biopsy. * Past or present HIV or hepatitis B or C infection. * Severe medical problems affecting organs or psychiatric illnesses that could interfere with the safety of the patient in the trial. * Pregnancy or breastfeeding women. * Patient will need to be informed and agree to undergo tumoral biopsy in the experimental arm.