TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris

Inclusion Criteria: * Healthy males or females, 16 to 55 years of age * Must be diagnosed as having moderate or severe acne vulgaris * ≥ 20 inflammatory lesions on the face * ≥ 20 non-inflammatory lesions on the face * ≤ 3 nodule/cyst acne lesions * Medically healthy * Females must be of non-childbearing potential Exclusion Criteria: * Systemic therapy with retinoids within six (6) months prior to study start * Topical use of prescription retinoids within four (4) weeks prior to study start * Oral antibiotics within four (4) weeks prior to study start * Topical dapsone, sulfacetamide, benzoyl peroxide, α-hydroxy/glycolic acid and retinol/retinaldehyde-containing products, and topical antibiotics, anti-inflammatory medications and corticosteroids on the face within two (2) weeks prior to study start * Facial procedures, including lasers, peels, and dermabrasion, within two (2) months prior to study start