During this project the effect of modified wheat bran on colon health and systemic health will be evaluated in a long-term intervention study in healthy and obese subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
50
20 g each day
20 g each day
KU Leuven
Leuven, Vlaams-Brabant, Belgium
The incremental plasma short-chain fatty acid concentrations will be measured using GC-FID after an intervention with wheat bran/placebo
Time frame: 1 month
Changes in glucose levels (mg/dL)
Time frame: 1 month
Changes in insulin levels (pmol/L)
Time frame: 1 month
Changes in cholesterol levels (mg/dL)
Time frame: 1 month
Changes in free fatty acids levels (mmol/L)
Time frame: 1 month
Changes in triglyceride levels (mg/dL)
Time frame: 1 month
Gut permeability using 51-Cr-EDTA
Time frame: 1 month
Total gastrointestinal transit time
Time frame: 1 month
Changes in gut microbiota before and after the intervention using 16S rRNA sequencing
Time frame: 1 month
Changes in metabolite patterns in the feces before and after the intervention using gas chromatography coupled to mass spectrometry
Time frame: 1 month
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