The purpose of this study is to confirm the protective effect and mechanism of anthocyanins on hyperuricemia patients with Cardiovascular disease.
Hyperuricemia patients who have the ability to complete the intervention study in the early stage of study were selected as the research subjects. A randomized controlled double blind control method was used to study the effect of one year of anthocyanins intervention. Serum UA levels, oxidative stress, AGEs, and endothelial function are detecting in patients with hyperuricemia who were treated with anthocyanins and placebo. Providing scientific basis of anthocyanins for the treatment with hyperuricemia and delaying atherosclerosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
320
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
General Hospital of Guangzhou Military Command of People's Liberation Army
Guangzhou, Guangdong, China
RECRUITINGMeasurement of serum uric acid levels in all patients
Serum uric acid (mg/dl) is determined by Uric Acid kit on an automated system.
Time frame: up to 1 months
Measurement of advanced glycation end products and its receptor level in all patients
Advanced glycation end products and its receptor level are determined by high efficiency liquid chromatography.
Time frame: up to 2 months
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