Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids

Peking Union Medical College Hospital30 enrolled

Overview

This study evaluates corticosteroids in the treatment of obstructive jaundice in autoimmune pancreatitis and/or immunoglobulin G4 (IgG4)-related sclerosing cholangitis in adults. Half of participants will receive corticosteroids alone, while the other half will receive corticosteroids with biliary stent at the beginning.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Autoimmune Pancreatitis IgG4-related Sclerosing Cholangitis Obstructive Jaundice

Interventions

corticosteroidsDRUG

prednisone 0.6mg/kg/d

biliary stentPROCEDURE

placement of biliary stent during endoscopic retrograde cholangiopancreatography (ERCP)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adults greater than 18 years-old; * autoimmune pancreatitis and/or IgG4-related sclerosing cholangitis; * obstructive jaundice Exclusion Criteria: * malignancies; active infections; * pregnancy or breast feeding; * standard contraindications to ERCP; * unwillingness or inability to consent for the study

Locations (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Clinical remission rate of obstructive jaundice

Time frame: Day 60

Central Contacts

Aiming Yang, M.D.

CONTACT

+86-10-69151593 yangaiming@medmail.com.cn

Data from ClinicalTrials.gov

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