The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.
Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner. Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.
Study Type
OBSERVATIONAL
Enrollment
219
Queen's University
Kingston, Ontario, Canada
Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST)
Participants are required to give a speech and an arithmetic test in front of a panel. Saliva samples are collected at 8 points throughout the test.
Time frame: 2 hours after beginning of Time B Appointment
Mood and Anxiety Symptom Questionnaire (MASQ)
Self-report scale of general distress (GD), anhedonic depression (AD), and anxious arousal (AA) symptoms
Time frame: Administered at first baseline appointment and covers past 2 weeks
Reward Responsivity: Probabilistic Reward Task
Computerized task that requires participants to choose between two stimuli and develop a response bias to the more frequently rewarded stimulus.
Time frame: Administered at second baseline appointment
Snaith Hamilton Pleasure Scale (SHAPS and SHAPS-C)
Self-report of anhedonia symptoms
Time frame: Administered at first baseline appointment and covers past 2 weeks prior to interview
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