Open Lung Approach Versus Standard Protective Strategies

Fundación para la Investigación del Hospital Clínico de Valencia36 enrolled

Overview

The aim of this study was to compare the effects of adding a recruitment maneuver (RM) to low tidal volume (VT) ventilation, with or without an individualized post-RM positive end-expiratory pressure (PEEP) setting in lung-healthy patients during anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Lung Collapse

Interventions

OLAPROCEDURE

PEEP titration trial for best Cdyn after the alveolar recruitment maneuver

RM-5PROCEDURE

Fixed standard PEEP after the alveolar recruitment maneuver

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status I-III undergoing elective major abdominal surgery including pancreatic-duodenectomy, gastrectomy and liver resection Exclusion Criteria: * i) laparoscopic surgery, ii) patients with previous respiratory disease.

Outcomes

Primary Outcomes

driving pressure

The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications

Time frame: intraoperative

Secondary Outcomes

ventilatory efficiency

Ventilatory efficiency measured with volumetric capnography which includes dead space and tidal elimination of carbon dioxide.

Time frame: intraoperative

Data from ClinicalTrials.gov

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