Clinical Trial of Adjuvant Chemotherapy Followed by Concurrent Chemoradiotherapy Compared With Adjuvant Chemotherapy Alone in Patients With Gallbladder Carcinoma and Extrahepatic Cholangiocarcinoma

Inclusion Criteria: * The patients with pathologic diagnosis of gallbladder carcinoma (GBCA) or extrahepatic cholangiocarcinoma (EHCC) after radical resection. * The patients with pathologic stage T2-4 or N1 in R0 resection or positive resection margins (R1). * Aged 18 to 70 years old, male or female, body condition score generally ECOG 0～2, expected survival ≥ 6 months. * Subjects were no major organ dysfunction, blood, liver, kidney and heart function was normal, the specific requirements of laboratory indicators: * Blood: Absolute neutrophil count \> 1.5 × 109 / L, Platelet count \> 100 × 109 / L, Hb \> 8.0g/dl. * Liver function: serum bilirubin less than 1.5 times the upper limit of normal; ALT and AST less than 2.5 times the upper limit of normal. * Renal function: creatinine less than 1.5 times the upper limit of normal. * Patients who can understand the circumstances of this study and signed informed consent. Exclusion Criteria: * Pregnancy, breast-feeding patients； * Patients received prior anticancer therapy for the current malignancy or upper abdominal radiotherapy or chemotherapy at any time. * Patients with malignant ascites. * Patients with purulent and chronic infected wounds which delayed healing. * Patients with liver, kidney and heart failure and coronary heart disease, angina, myocardial infarction, arrhythmia, cerebral thrombosis, stroke and other serious cardiovascular and cerebrovascular disease; * Patients has a history of mental illness and difficult to control; * Patients who was considered inappropriate to participate in the trials by the researchers.