A significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children. There is no specific study on the population and the consequences of overweight in the lives of these long-term patients. Narcoleptic patients gain weight significantly at the onset of their illness. It is also known that weight gain is not related to the treatment of narcolepsy. The etiology of obesity in narcoleptic patients is not established. Several assumptions were made (physical activity, leptin diet, metabolism). The reason and the pathophysiology of overweight and obesity in this population therefore remain unclear. In this study, potential change in the total metabolism (24h) for narcoleptic children that could explain their tendency to obesity will be assessed ?
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
24
Service d'Exploration et pathologie du sommeil, Hôpital Femme Mère Enfant
Bron, France
Determination of the metabolism at home
Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at home (15 days including scholar and non-scholar days).
Time frame: 15 days
Determination of the metabolism at hospital
Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at hospital over 24 hours.
Time frame: 18 days
Basal energy expenditure
The basal metabolism (MET) measured by accelerometer (Actical, BodyMedia SW Actiheart) will be compared to the values of energy expenditure (kcal) measured by indirect calorimetry fasting.
Time frame: 18 days
Energy expenditure and diet-induced thermogenesis
Energy expenditure (kcal) measured by indirect calorimetry after lunch (with counting calories ingested).
Time frame: 18 days
Sympathetic activity
Estimated from IBI (Interbeat Interval) measured by Actiheart.
Time frame: 18 days
Food intake
Caloric intake evaluation (kcal per day) during hospitalization (food intake recording) and at home during three days ( two days during the week and one day during the week-end) evaluated by questionnary.
Time frame: 18 days
Fasting peptide YY
Time frame: 18 days
Body weight
bodyweight (kg)
Time frame: 18 days
Body height
Body height (cm)
Time frame: 18 days
Waist and hips circumference
Waist and hips circumference (cm)
Time frame: 18 days
Measurement of neck
Measurement of neck (cm)
Time frame: 18 days
Anthropometric measurements
Measurement of BMI Z-score
Time frame: 18 days
Appetite
appetite evaluation by visual analog scale before each meal
Time frame: 18 days
Hunger
hunger evaluation by visual analog scale before each meal
Time frame: 18 days
Fasting IL6-8 levels
Time frame: 18 days
Fasting adiponectin
Time frame: 18 days
Fasting resistin
Time frame: 18 days
Fasting MCP1
Time frame: 18 days
Fasting PostPrandial
Time frame: 18 days
Fasting GLP1 (glucagon-like peptide-1)
Time frame: 18 days
Fasting Hba1C
Time frame: 18 days
Body mass index z score
Time frame: 18 days
sleep duration
Time frame: 18 days
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