Bioavailability and Mucosal Bioactivity of Avmacol® in Healthy Volunteers

Inclusion Criteria: 1. Age ≥ 18 years. 2. Members of all racial and ethnic groups are eligible. 3. Smoking and non-smoking people are eligible. The tobacco use assessment form must be completed following consent and registration. 4. No chronic use of steroids 5. Karnofsky Performance Scale ≥90% 6. Able to provide written, informed consent 7. For women of child-bearing potential (WOCBP), a negative urine pregnancy test must be documented within 7 days prior to the first study intervention 8. Willing to avoid cruciferous vegetables during the study interventions 9. Willing to avoid grapefruit or grapefruit juice 48 hours prior to or during the study 10. Willing to avoid daily vitamins and anti-inflammatory medications prior to and during the study 11. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study and for the duration of study participation. 12. Willing and able to perform self-collection of buccal cells as stated in the instruction manual Exclusion Criteria: 1. No current or former diagnosis of cancer, with the exception of: carcinoma-in-situ of breast or cervix; non-melanomatous skin cancer; T1-2, N0, M0 differentiated thyroid carcinoma; superficial bladder cancer; T1a or T1b prostate cancer comprising \< 5% of resected tissue with normal prostate specific antigen (PSA) since resection 2. No use of chronic prescribed medications which are potent inducers or inhibitors of CYP3A4 3. Chronic use anticoagulation