Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

University of Minnesota40 enrolled

Overview

This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.

This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women aged 35-55 years.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Impaired Glucose Tolerance

Interventions

SucraloseOTHER

Sweetner

SteviaOTHER

Sweetner

Eligibility

Sex: ALLMin age: 35 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Generally health adult men and women aged 35-55 years old - Exclusion Criteria:Adults will not be eligible who have chronic disease (cancer, CHD, diabetes, chronic kidney disease); pregnant or breast feeding; menopausal; has a history of bariatric surgery; taking prednisone/steroids, taking medication for PCOS, or take medications that influence blood glucose. \-

Locations (1)

ECRC

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

2-hour glucose

An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose

Time frame: 14 days

Secondary Outcomes

Gut microbiome

Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota.

Time frame: 14 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.