24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy

Inclusion criteria * Open-angle glaucoma patients (primary open-angle glaucoma, exfoliative, or pigmentary glaucoma) insufficiently controlled on branded, or generic latanoprost monotherapy (IOP \> 20 mm Hg as determined by 2 separate IOP measurements at 10:00 ± 1 hour) * Patients with signs, or symptoms of ocular surface disease. * Only those open-angle glaucoma subjects who, according to the opinion of the principal investigator, require further IOP reduction. * Patients must have demonstrated at least 20% IOP reduction at 10:00 (± 1 hour) and who are treated with branded, or generic latanoprost monotherapy for at least 3 months. * Only subjects with open-angle glaucoma that have exhibited (prior to latanoprost therapy) untreated, sitting IOP evaluated with Goldmann tonometry between 25-39 mm Hg at 10:00 (± 1 hour). * Age between 21-85 years * Mild to moderate glaucomatous disc damage and visual field loss (less than -12 dB mean deviation visual field loss attributed to glaucoma * Those with 0.8 or better vertical cup-to-disc ratio and visual acuity greater than 0.1 in the study eye. * Open anterior chamber angles. * Those who have to demonstrate a reliable visual field (at least two visual fields with less than 20% fixation losses, false positives, or negatives) * Patients who understand study instructions, are willing to attend all follow-up appointments and will comply with study medication usage. Exclusion criteria * Patients with a history of less than 10% IOP decrease on any IOP-lowering medication. * Those with evidence of concurrent conjunctivitis, keratitis, or uveitis in either eye. * Subjects with a history of inadequate adherence; intolerance, or contraindication to either prostaglandins, β-blockers, dorzolamide, or benzalconium chloride (BAK) * Patients with severe ocular surface disease, previous intraocular conventional or laser surgery in the study eye (within 6 months prior to enrolment); previous history of ocular trauma; use of corticosteroids (within 3 months before the enrolment) and use of contact lenses. * Those that on baseline examination show clinical evidence of inflammation, signs of ocular infection (except blepharitis), signs of any corneal abnormality that will affect subsequent IOP measurements * Subjects that show unwillingness to participate in the trial. * Females of childbearing potential or lactating mothers.