The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease

Inclusion criteria: * men and women * 20 to 70 years with dry eye disease * low tear break-up time (TBUT) (\<10 seconds) or low Schirmer score (with application of local anesthetic) (\<10mm for 5 min) or presence of corneal and conjunctival damage at the time of screening. * blood level of triglyceride higher than 150 mg/dL or HDL-cholesterol less than 40 and 50 mg/dL for men and women, respectively. Exclusion Criteria: * under the anti-inflammatory eye drops for dry eye (topical steroid and topical cyclosporin) * hypolipidemic medication within 3 months of study entry * history of chronic disease * any clinical trial using an investigative medicinal product within 2 months before the first dose of the present study * allergic or hypersensitive to any of the ingredients in the test products. * women who were pregnant or breast feeding * a history of alcoholism or drug abuse or medical or psychological conditions