Hemodynamic Impact of Hyperbaric Versus Isobaric for Spinal Anesthesia During Cesarean Delivery

Seoul National University Hospital72 enrolled

Overview

The purpose of this study is to compare the frequency of hypotension between hyperbaric anesthetics and isobaric anesthetics during cesarean section and determine whether continuous infusion of phenylephrine is effective in mothers who received hyperbaric anesthetics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Hypotension

Interventions

BupivacaineDRUG

spinal anesthesia with hyperbaric bupivacaine

LevobupivacaineDRUG

spinal anesthesia with isobaric levobupivacaine

PhenylephrineDRUG

continous infusion of phenylephrine

normal saline

Eligibility

Sex: FEMALEMin age: 19 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * pregnant woman scheduled for elective cesarean delivery under spinal anesthesia Exclusion Criteria: * patients who refuse involved * patients who have pre-eclampsia * patients who have heart disease * patients who fetal distress is suspicious

Locations (1)

Seoul National University Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Number of hypotension events with treatment related

blood pressure was obtained every 1min. A 20% decrease or more decrease in SAP compared to baseline was considered as hypotension. Hypotensive events during first 30 min was recorded as primary outcome.

Time frame: during 30min after spinal anesthesia

Secondary Outcomes

total dose of phenylephrine

Time frame: during the surgery

Data from ClinicalTrials.gov

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