Previous research has shown that people who have been hospitalised for pneumonia are more likely to die of conditions such as heart attacks, stroke and cancer in the weeks to months after their illness. This risk is linked to raised levels of inflammation. Laboratory research shows that vitamin D can help to clear inflammation. Vitamin D deficiency is very common in the United Kingdom. The investigators are conducting this study to find out if taking vitamin D can hasten long-term recovery from pneumonia by reducing inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
3
Capsules to be dispensed using an electronic dispenser to allow real time logging of adherence.
To attain samples for immunological testing
For volumetric quantification of lung abnormalities
Barts Health NHS Trust
London, United Kingdom
Plasma IL-6 concentrations
IL-6
Time frame: after 6 weeks of vitamin D3 supplementation
Serum CRP
CRP
Time frame: after 6 weeks of vitamin D3 supplementation
Total white cell count and differential white cell count in induced sputum samples
WBC and differential counts
Time frame: after 6 weeks of vitamin D3 supplementation
Immune cell phenotypes in peripheral blood
flow cytometry phenotypes, blood
Time frame: after 6 weeks of vitamin D3 supplementation
Immune cell phenotypes in induced sputum samples
flow cytometry phenotypes, induced sputum
Time frame: after 6 weeks of vitamin D3 supplementation
Plasma concentrations of pro- and anti-inflammatory mediators in peripheral blood
Cytokines, lipid mediators, blood
Time frame: after 6 weeks of vitamin D3 supplementation
Plasma concentrations of pro- and anti-inflammatory mediators in induced sputum samples
Cytokines, lipid mediators, induced sputum
Time frame: after 6 weeks of vitamin D3 supplementation
Plasma concentrations of pro- and anti-inflammatory mediators in supernatants from whole blood stimulated with antigens ex-vivo
Cytokines, lipid mediators, stimulated blood
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Symptom questionnaire for recent symptom history
To be dispensed using an electronic dispenser to allow real time logging of adherence.
Time frame: after 6 weeks of vitamin D3 supplementation
Whole blood transcriptional profiles
mRNA
Time frame: after 6 weeks of vitamin D3 supplementation
Volumes of lung abnormalities on chest CT imaging
CT data
Time frame: after 6 weeks of vitamin D3 supplementation
Pneumonia symptom scores
CAP-Sym scores
Time frame: after 6 weeks of vitamin D3 supplementation