Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum

Inclusion Criteria: * Willing and able to give written informed consent * Age 18 years to 75 years. * Both males and females. * Ankle branchial index of 0.8 or above. Exclusion Criteria: * Diabetics will be excluded as the Ankle Branchial Index (ABI) result is considered an unreliable due the possible presence of arteriosclerotic plaques (lead pipe rigidity). * Patients who have participated in experimental drug studies within 30 days of entering this study. * receiving chemotherapy or radiotherapy for malignant diseases or any other indication * Patients taking corticosteroids or other immunosuppressive medications * Clinically malnourished patients or those with recent (last 4 weeks without treatment) serum albumin of less than 30g/l. * Patients with current or past history of acute deep vein thrombosis. * Patients with current signs and/or symptoms of cardiac, renal or hepatic failure. Renal failure defines as Creatinine * Patients with signs and/or symptoms of peripheral neuropathy. * Patients with signs and/or symptoms of ATROPHIE BLANCHE or other conditions associated with non-chronic venous insufficiency ulceration of the lower leg. * Patients with signs and/or symptoms of immunocompromized sates or recent (last 4 weeks ) T cell subset (CD4) count of less than 200 cells / ml. * Patients showing clinical signs and/or symptoms of anaemia or current or recent(last 4 weeks without treatment) haemoglobin level of less than 8g/dl