Cell Therapy by Autologous BMC for Large Bone Defect Repair

Inclusion Criteria: * patients aged between 50. and 90. years with proximal humerus fractures * indication for open reposition and internal stabilisation with a proximal fixed- angle plate for humerus (PHILOS, Synthes, Oberdorf, Swiss): * 2-, 3- or 4-fragment fracture according to Neer * dislocation of \>10 mm between fragments and/or * angle of \> 45° between fragments and/or * dislocation of tuberculum majus \> 5 mm * negative pregnancy test of premenopausal women * signed informed consent for surgery and participation in the clinical trial Exclusion Criteria: * contraindications against administration of Investigational medicinal product (IMP) is pregnancy and nursing * dislocation fracture * known psychic disorder that leads to incompliance (e.g. dementia, schizophrenia, major depression) * pathologic fractures caused by other underlying diseases * fracture-induced nerve damage * tumor disease with recent adjuvant therapy or treatment during the last 3 months (e.g. chemotherapy, radiotherapy), untreated tumor diseases * known hypersensibility against components of the transplant * participation in a clinical trial during the last 3 months prior to this study