Investigate Absorption, Metabolism, Excretion, and Mass Balance of Pacritinib

Inclusion Criteria: * Non-smoking men between 18 and 55 years of age (inclusive) * ECG within normal limits (according to the criteria used by QPS Netherlands BV including QTc interval (less than or equal to 450 m/sec) * Normal vital signs measurements \[defined as blood pressure (BP) between 90-140 mmHg systolic and 50-90 mmHg diastolic, resting heart rate (HR) between 40-100 beats/min, temperature (T) less than or equal to 37.6 degree C\]) * Body mass index of 19.0-29.0 kg/m2 inclusive * Negative history of drug abuse or alcoholism within 1 year prior to Day 1 * Negative tests on drug and alcohol screen at Screening and Check-in * Negative hepatitis panel including hepatitis B-surface antigen HBsAg\], hepatitis C antibody \[anti-HCV\] and negative human immunodeficiency virus antibody (HIV) * No clinical laboratory value outside of the normal reference range unless deemed not clinically significant by the Investigator in consultation with the Sponsor * Fertile male subjects and fertile female sexual partners of male subjects agree to use effective birth control methods throughout the entire study. Female partners of childbearing potential must use highly effective methods (defined as those resulting in a failure rate of \<1% per year when used consistently and correctly). The contraceptive methods considered highly effective are intrauterine devices and hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices, or injections with prolonged release). Male subjects must use a condom with spermicide paste for the duration of the study and for 90 days after the EOS evaluation. When abstinence is used as a method of birth control, only true abstinence is acceptable, when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (calendar, ovulation, symptothermal, and post-ovulation methods) and withdrawal are not acceptable methods of contraception * Agreement to not donate sperm throughout the entire study and for 3 months after the end of the study * Willingness to comply with the protocol, including restrictions on diet, physical activity, and use of alcohol, medications, and other drugs during the study * Comprehend and willingness to sign an approved informed consent form for the study * At least one bowel movement a day Exclusion Criteria: * Participation in another radioactive clinical trial within the past 12 months * Actively participating in an experimental therapy study or who have received experimental therapy within 90 days of Day 1 * Use of any other prescription medication within 21 days of Day 1, unless approved by Sponsor * Use of over-the-counter (OTC) medications or nonprescription preparations (including vitamins, minerals and phytotherapeutic/herbal/plant-derived preparations) that is known to induce drug-metabolizing enzymes, including CYP450 enzymes within the 7 days preceding Day 1 (except for spermicidal/barrier contraceptive products and paracetamol) * Consumption of alcoholic beverages within 72 hours prior to Check-in (Day -1) * Consumption of grapefruit- and grapefruit-containing products within 7 days prior to Day 1 * Consumption of xanthine containing beverages such as coffee, including energy drinks containing caffeine or tea within 2 days of Day 1 * Clinically significant abnormal physical finding at Screening * Any severe acute or chronic medical condition, psychiatric condition, or laboratory abnormality that in the Investigator's opinion may increase the risk associated with study participation or administration of study treatment, or interfere with the interpretation of study results (such as gastrointestinal surgical history (except appendectomy), ileus or obstructive uropathy) * Diarrhea, nausea or vomiting within 7 days of Day 1 * History of additional risk factors for torsade de pointes (TdP) (e.g. heart failure, hypokalemia defined as serum potassium \<3.0 mmol/L, family history of Long QT Syndrome) * Any illness during the 4 weeks prior to Day 1, unless deemed NCS by the Principal Investigator * Any history of severe allergic reaction (including drugs, food, insect bites, environmental allergens) * Known history or presence of food allergies or any condition known to interfere with the absorption, distribution, metabolism or excretion of drugs * Any surgical procedures within 72 hours of Day 1 * Blood draws of more than 400 mL during the conduct of any clinical study within 90 days prior to Day 1 * Poor peripheral venous access * Donation of blood 30 days prior to Screening through end of study * Employment in a position that exposes the subject to radiation or requires that the subject's degree of radiation exposure be monitored (e.g. radiology technician)