The purpose of this study is to compare the exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.
In patients with chronic respiratory failure, pulmonary rehabilitation is recognized as an evidence-based treatment in improving exercise capacity, muscle strength, dyspnea, and quality of life. Oxygen supplementation during exercise induced dose-dependent improvement in endurance and symptom perception in chronic obstructive pulmonary disease patients. Recently, nasal high flow therapy which consists of high flow gas with an FiO2 ranging from 0.21 to nearly 1.0 adjusted by an oxygen blender, brought to body temperature, and saturated with water through an in-line humidifier is available. The present study is randomised to compare the effect of exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
32
The nasal high flow therapy has enabled high flow oxygen to be derived through nasal cannula. This mode not only allows constant FiO2 during peak inspiratory flow but also confers benefits including a low level of continuous positive airway pressure with increased end-expiratory lung volume and reduced work of breathing, partly through intrinsic positive end-expiration pressure compensation and dead space washout. The inspired gases are warmed and humidified, improving comfort and possibly reducing airway inflammation, leading to improved drainage of respiratory secretions.
National Hospital Organization Minami Kyoto Hospital
Jōyō, Kyoto, Japan
Walk distance (measured by six minutes walking test)
Time frame: Four weeks
Six minutes walking test (minimum Oxygen Saturation of Arterial Blood Measured by Pulse Oximeter (SpO2) et.)
Time frame: Four weeks
Exercise tolerance test (exercise time et.)
Time frame: Four weeks
Body composition measured by InBody (muscle mass et.)
Time frame: Four weeks
Arterial blood gas
Time frame: Four weeks
Inflammation (CRP et.)
Time frame: Four weeks
Nutritional status (body mass index(kg/m2) et.)
Time frame: Four weeks
Sympathetic activity (Catecholamine et.)
Time frame: Four weeks
Dyspnea (Modified Borg scale)
Time frame: Four weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.