A Phase 1 Safety Study in Adults With Schizophrenia

Inclusion Criteria: * Has a body mass index (BMI) of 18.0-35.0 kg/m\^2, inclusive * Has a primary diagnosis of schizophrenia * Capable of understanding and complying with the procedures, requirements, and restrictions of the protocol. * Appropriate for outpatient treatment * Agrees to abide by the contraception requirements specified in the protocol for the duration of the study or is surgically sterile * Willing and able to provide government-issued identification * Is in good physical health * Agrees to maintain normal tobacco use as well as normal activities/exercise throughout the study * Additional criteria may apply Exclusion Criteria: * Is currently pregnant or breastfeeding * Initiated first antipsychotic treatment within the past 12 months, or \<1 year has elapsed since the initial onset of active-phase schizophrenia symptoms * Poses a current suicide risk at Visits 1 or 2 * Has a history of poor or inadequate response to treatment with olanzapine * Has used a long-acting injectable antipsychotic medication in the last 6 months with the exception of 3-month paliperidone, which must not have been received within the past 12 months. * Requires or has had electroconvulsive therapy (ECT) treatment in the 6-month period prior to Visit 1 * Has a diagnosis of alcohol or drug use disorder (with the exception of nicotine) * Has taken opioid agonists (codeine, oxycodone, tramadol, or morphine) within the 14 days prior to Visit 1 and/or anticipates a need to take opioid medication during the study period. * Has taken opioid antagonists including naltrexone (any formulations) and naloxone within 60 days prior to Visit 1, or has used any extended-release formulation of an opioid antagonist within 2 months prior to screening * Tests positive for amphetamines/methamphetamine, cocaine, barbiturates, opioids (codeine, hydrocodone, hydromorphone, methadone, morphine, oxycodone, oxymorphone, and buprenorphine), phencyclidine and benzodiazepines. * Has a known or suspected intolerance, allergy or hypersensitivity to olanzapine or opioid antagonists. * Additional criteria may apply