The investigators hypothesis is that use of IV acetaminophen will significantly decrease use of post-operative opioid consumption and enhances recovery after colorectal surgery.
All patients undergoing laparoscopic and open colorectal surgery are randomized to receive either IV acetaminophen or placebo. All patients received an opioid patient controlled anesthesia (PCA). IV acetaminophen (1 gram) or placebo is given 30 minutes prior to operation and every 6 hours thereafter for up to 5 days post-operatively or discharge. The investigators primary endpoint is to evaluate opioid consumption during the patient's hospital stay. The investigators secondary endpoints are to evaluate return of gastrointestinal function (ROGIF), time to diet ordered (TTDO), length of hospital stay (LOHS) and occurrence of ileus. Pain is measured with the pain visual analog scale score (PVASS) at 3, 8, 24 and 48 hours.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
105
1 gram every 6 hours
100 ml of normal saline every 6 hours
Total opioid consumption
Time frame: 48 hours
pain control base on pain visual Analogue Scale Score (1-10)
Time frame: 48 hours
time to Return of GI function (ROGIF) [Flatus or bowel movement]
Time frame: through study completion, an average of 5 days
Time to diet ordered (TTDO)
Time frame: through study completion, an average of 5 days
Length of hospital stay (LOHS)
Time frame: through study completion, an average of 5 days
Occurrence of ileus
Time frame: through study completion, an average of 5 days
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