Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the likelihood of progression to dementia. Dementia's, such as Alzheimer's disease, typically have a long prodromal stage with brain changes identifiable from the earliest stages of neuropathology, providing an opportunity for intervention. Switching to a strategy of earlier identification and prevention would significantly reduce prevalence and the associated cost. The purpose of this pilot study is to evaluate the use of vitamin D supplements in community dwelling older adults as a lifestyle approach that may support cognitive and physical functioning. The research will incorporate several stages including an initial in-depth screening process, a novel and sensitive cognitive battery, 6 month double blind placebo controlled intervention of vitamin D3 (cholecalciferol) and a concluding participant feedback interview. These results will be used to assess the feasibility of recruiting and assessing community dwelling older adults for extensive nutrition related cognitive studies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
60
University of Dublin, Trinity College
Dublin, Ireland
Global Cognitive Function
Global cognitive function will be assessed using the validated Montreal Cognitive Assessment for all participants
Time frame: 26 weeks
Executive Function
Executive function will be assessed according to the validated Trails Making Task Part A and B
Time frame: 26 weeks
Memory
Episodic memory will be assessed according to the Wescher Memory Scale
Time frame: 26 weeks
Attention and Visual Reasoning
Attention and visual memory will be assessed using 2 validated measures: the Sustained Attention to Response Task and the Cambridge Mental Disorders of the Elderly Examination Visual Reasoning Test
Time frame: 26 weeks
Muscle strength
Muscle strength in the participants will be assessed using a clinical dynamometer to measure grip strength
Time frame: 26 weeks
Physical function
Physical function will be assessed using the Timed up and Go measure
Time frame: 26 weeks
Systemic inflammation
Serum will be analysed for levels of specific cytokines
Time frame: 26 weeks
Change in Blood Level of Vitamin D (25-hydroxyvitamin D)
Serum will be analysed for change in levels from baseline
Time frame: 0, 12 and 26 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.