Comparison of His Bundle Pacing and Bi-Ventricular Pacing in Heart Failure With Atrial Fibrillation

Inclusion Criteria: * Subject is at least 18 years old * Subject or authorized legal guardian or representative has signed and dated the Informed * Subject is expected to remain available for follow-up visits at the study center * Subjects with heart failure NYHA Class II-IV * Subjects with LVEF no greater than 40% * Subjects with persistent atrial fibrillation or atrial flutter with uncontrolled ventricular rate Exclusion Criteria: * Subjects with the width of ECG Q, R, S wave (QRS) complex \>120ms * Subjects with life expectancy less than 3 years * Subjects with mechanical right heart valve * Subjects with primary valvular disease * Subjects with heart transplant, or is currently on a heart transplant list * Subjects who are pregnant, or of childbearing potential and not on a reliable form of birth control * Subjects with significant renal dysfunction, as manifested by serum creatinine level \>2.5 mg/dl or ≥275 μmol/L or estimated glomerular filtration rate (GFR) ≤30 mL/min/1.72 m2, which is documented within the 30 days prior to enrollment or at baseline. * Subjects with significant hepatic dysfunction, as evidenced by a hepatic function panel (serum) \> 3 times upper limit of normal, which is documented within the 30 days prior to enrollment or at baseline. * Subjects with chronic or treatment-resistant severe anemia (hemoglobin \<10.0 g/dL), which is documented within the 30 days prior to enrollment or at baseline