Demonstrate in a large multicenter population the diagnostic performance of a pre-commercial on-site, local, CT angiography derived FFR algorithm in comparison to invasive FFR.
To retrospectively evaluate the diagnostic accuracy of FFRCT, in patients with known or suspected CAD. the investigators propose to do technical assessment of the software and evaluate how different parameters effect the outcome. Validate the FFTCT outcome by comparing the FFRCT values with invasive FFR values from retrospective patient data. To analyze the potential of FFRCT on decision making and prognosis.
Study Type
OBSERVATIONAL
Enrollment
352
ErasmusMC
Rotterdam, South Holland, Netherlands
Diagnostic accuracy of local reduced order CFD and machine learning based CT angiography derived FFR, both validated against invasive FFR. Measured at both vessel and patient level.
Time frame: 6 months
Influence of calcium on diagnostic accuracy of CT angiography derived FFR.
Time frame: 6 months
Confidence intervals of CT angiography derived FFR
Time frame: 6 months
Direct vessel based comparison between CT angiography derived FFR and QCT stenosis measurements
Time frame: 6 months
Analysis of anatomically mild stenosis (<50% lumen diameter reduction) but functionally significant (invasive FFR ≤ 0.80)
Time frame: 6 months
Long term clinical outcome of CT angiography derived FFR
Time frame: 12 months
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