Biology and Experience of Eating in Women With Obesity

Inclusion Criteria: * Obese, as defined by BMI greater than or equal to 30 * Self-reported binge eating as defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), in the last 4 weeks * If sexually active with men, must agree to use birth control until the final study visit is complete (e.g., barrier methods, oral contraceptive) * Subject must be able to complete written informed consent procedures and be able to comply with the requirements of the study. Exclusion Criteria: * Pregnant or breastfeeding * Severe hypotension (\< 90/60 mmHg) * Recent or current use of vasoconstrictor or vasodilator medication * Current or history of diabetes * Allergies to any ingredients in naloxone hydrochloride * History of or current alcoholism or drug dependence * Bulimia Nervosa as defined in DSM 5 * Current or past use of opiate-containing medications in the last 30 days * Plan to use opiate-containing medications during study participation period * Medical conditions that are contraindicated with intranasal procedures: Nasal septal abnormalities, nasal trauma, epistaxis, excessive nasal mucus, and intranasal damage caused by the use of substances (e.g., cocaine) * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the subject or the quality of the data