Approximately 50% of people in the world are infected with H. pylori, and its eradication rate fail to exceed 80% and even fails into an unacceptable range.Various risk factors for infection include lower socioeconomic status, younger age, and geographic location.In the present study, investigators aimed to perform a prevalence survey about risk factors for H. pylori infection.To obtain the higher eradication of H. pylori and find out the relevance between the diverse infection and clinical drug focused on refractory H. pylori infection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,845
The patients who have failed more than 2 eradication courses with standardized treatment were the refractory infection of H. pylori group,and patients who succeeded at the first standardized treatment were the successful treatment group
The intervention focused on the results from the result of 13C-urea breath test after treatment.The two groups were treatment based on the antibiotic susceptibility testing. Eight weeks after treatment,a 13C-urea breath test was performed on patients.The successful treatment group were patients with negative in 13C-urea breath tests in the first treatment. The refractory infection of H. pylori group were treatment failure patients after the second standardized treatment.
The People Hospital of Baoan Shenzhen
Shenzhen, Guangdong, China
RECRUITINGLonghua Branch of Shenzhen People Hospital
Shenzhen, Guangdong, China
RECRUITINGPeople Hospital of Luohu,Shenzhen
Shenzhen, Guangdong, China
RECRUITINGShenzhen Second People's Hospital
Shenzhen, Guangdong, China
RECRUITINGThe eradication rate of H. pylori reach to 95%
The eradication rate of untreated cases reach to 98%.The eradication rate of refractory cases reach to 90%.
Time frame: 1.5 year
Obtain the first resistant pattern to antibiotics in shenzhen area
The results of antibiotic susceptibility testing were analyzed in this study.More than 1800 patients were participated,these patients were representative in five hospitals of shenzhen area.
Time frame: 1.5 year
The proportion of mix infection of H pylori in a total of 40 patients in two groups
Analyzed the next-generation sequencing data,obtain the proportion of mixed infection with different H. pylori strain in refractory cases.
Time frame: 2.5 year
The incidence of adverse effects in the eradicate treatment
A telephone interview was conducted at 4 weeks after treatment.And the 1845 patients was investigated using questionnaires of symptom checklist.A statistics table will be got.
Time frame: 2.5 year
The difference between microbial genes of different patients
By 2 or 3 metabolic pathways with significant differences, selected 40-50 different genes.
Time frame: 3 year
The relevance between mixed infection, microflora structure and risk factors
Analyzed the next-generation sequencing data,obtain the results of mixed infection and microflora structure in a total of 40 patients in two groups.And the patients was investigated using questionnaires of risk checklist.The collected data were subsequently analyzed using SPSS. For checking the relationship between mixed infection, microflora structure and risk factors.
Time frame: 3 year
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