Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF)

Inclusion Criteria: * Adult patients (≥ 18 years) * Provision of informed consent prior to any study specific procedures * Female patients of childbearing potential may be entered if pregnancy testing is negative and the patient agrees to abstain from procreational sexual intercourse or must use double-barrier contraceptive measures for the duration of the study * Presence of an indwelling external cerebrospinal fluid (CSF) access device (ventriculostomy or lumbar drain) * Presence of inflamed meninges as a result of documented or suspected meningitis or ventriculitis. Patients with both clinical symptoms (fever, headache, meningismus, and altered mentation) and laboratory parameters (CSF leukocytosis, defined as a CSF white blood cell count \[WBC\] of \>10 3, elevated CSF protein, defined as CSF protein of \>1g/l, reduced CSF glucose, defined as CSF glucose of \<0.3g/l, or a positive CSF Gram stain or culture) indicative of CNS infection were deemed to have definitive bacterial meningitis/ventriculitis. Inflamed meninges were defined as the presence of \>5 leukocytes/mm3 of CSF. Exclusion Criteria: * Patient has documented history of hypersensitivity or allergic reaction (urticaria, angiooedema, anaphylaxis, desquamative rash) to any β-lactam antimicrobial including cephalosporins (contraindication to cephalosporins) * Patient is pregnant or lactating and intends to continue breastfeeding * Severe renal insufficiency defined as creatinine clearance \< 50 mL/min. * Patients with conditions known or suspected to alter pharmacokinetics (i.e., burn or cystic fibrosis patients) * Refusal to participate * Person not affiliated with the social security