Stem Cell Fistula Plug in Post Surgical Leak Fistulas

Inclusion Criteria 1. Males and females 18-75 years of age. 2. Residents of the United States. 3. Patients with persistent symptomatic fistulas arising after gastro-esophageal resections, enteric or colonic resections or Bariatric surgeries. 4. Single-tract fistula 5. Have no contraindications to imaging evaluations: e.g. contrast allergies 6. Ability to comply with protocol 7. Competent and able to provide written informed consent 8. Must have failed standard conservative therapy which includes at least one endoscopic attempt to resolve fistula. Standard conservative management includes drainage of sepsis, antibiotics, nutritional support, etc. Endoscopic closure attempt with devices such as, but not limited to; endo-stitch, clipping, surgical sealants, etc. This attempt may be with or without diversion of the luminal contents by stenting. 9. Radiographic Imaging within 7 days of fistula plug placement (e.g. CT, PET, etc.). Exclusion Criteria 1. Inability to give informed consent. 2. Clinically significant medical conditions within the six months before administration of MSCs: e.g. myocardial infarction, active angina, congestive heart failure or other conditions that would, in the opinion of the investigators, compromise the safety of the patient. 3. Specific exclusions; a. Evidence of hepatitis B, C, or HIV 4. Investigational drug within thirty (30) days of baseline 5. A resident outside the United States 6. History of clinically significant auto-immunity (i.e. Inflammatory Bowel Disease). 7. Previous allergic reaction to a fistula plug. 8. If obtaining sufficient adipose tissue for manufacturing is not technically feasible 9. Allergic to local anesthetics 10. Pregnant patients or trying to become pregnant or breast feeding. 11. Non-enterocutaneous tracts 12. Fistula output \>2000 ml/day 13. Multiple or end fistulas 14. Fistulous tract \<2 cm in length 15. Fistulous tract or defect \>1 cm in diameter, 16. Fistulas opening into abdominal wall defect. 17. Diseased adjacent bowel, fistula in the radiation field, persistent distal obstruction or malignancy 18. Patients on immunosuppression or chemotherapy 19. Uncontrolled diabetes, i.e. blood sugar more than 200 20. Sepsis 21. Fistulas arising from a malignant lesion 22. Patients with obstructive malignancies 23. Patients with stage III and/or stage IV cancers. The investigators will exclude patients with stage III or IV cancers, poorly differentiated cancers and patients with less than accepted disease free surgical margins.