The purpose of FiSK Junior is to investigate whether intake of oily fish compared to poultry affects cardiovascular risk markers, cognitive function, and behaviour in healthy children.
The FiSK Junior study compares the effects of consuming oily fish versus poultry (control) in healthy 8-9 year-old Danish children. The children will be randomized to consume approximately 300 g/week of either oily fish or poultry for 12 weeks. Measurements and biological sampling will be performed at baseline and at the end of the intervention. The main objective of the study is to investigate the effect on cardiovascular risk markers, primarily blood pressure and plasma triacylglycerol. Moreover, the effects on cognitive function, behaviour, emotions and physiological stress response will be assessed. In addition, change in n-3 long chain polyunsaturated fatty acid status (compliance), anthropometry, body composition, vitamin D status, inflammatory markers, growth markers, physical activity and diet will be measured. Outcomes will be analysed with focus on potential gender- and genotype-specific effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
199
Department of Nutrition, Exercise and Sports, University of Copenhagen
Frederiksberg C, Denmark
Blood pressure
Time frame: At 12 weeks
Serum triacylglycerol concentration
Fasting blood level
Time frame: At 12 weeks
Serum LDL cholesterol
Time frame: At 12 weeks
Serum HDL cholesterol
Time frame: At 12 weeks
Serum insulin
Time frame: At 12 weeks
Plasma glucose
Time frame: At 12 weeks
Blood glycosylated haemoglobin (HbA1c)
Time frame: At 12 weeks
Heart rate
Time frame: At 12 weeks
BMI z-score
Time frame: At 12 weeks
Waist circumference
Time frame: At 12 weeks
Fat mass index by bioimpedance
Time frame: At 12 weeks
Cognitive function measured by the Cambridge Neuropsychological Test Automated Battery
Time frame: At 12 weeks
Response inhibition measured by Flanker test
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Time frame: At 12 weeks
Selective attention capacity measured by Stroop Test
Time frame: At 12 weeks
Attention measured by the D2 Test of Attention
Time frame: At 12 weeks
Saliva cortisol after cold-pressor task
Time frame: At 12 weeks
Hair cortisol
Time frame: At 12 weeks
Compliance measured by content of n-3 long-chain polyunsaturated fatty acids in red blood cells
Time frame: At 12 weeks