Topical Ruxolitinib for the Treatment of Vitiligo

Inclusion Criteria: * Clinical diagnosis of vitiligo. * At Visit 1 (Baseline/Day 1), have had vitiligo covering at least 1% of total body surface area (BSA) on the scalp, trunk or limbs (excluding nails). * Female subjects of childbearing potential must agree to use a highly effective method of contraception throughout the study and for at least four weeks after the last dose of assigned treatment. Male subjects must also use contraception, such as barrier method with spermicide. * If receiving concomitant medications for any reason, must be on a stable regimen and willing to stay on a stable regimen. * Must be willing to washout of other vitiligo treatments. All treatments for vitiligo are prohibited during the course of the study. Exclusion Criteria: * Other skin conditions at Baseline that would interfere with evaluation of vitiligo. * Pregnant/breastfeeding females, or females of childbearing potential not using highly effective contraception. Women of childbearing potential must test negative for pregnancy and use contraception for at least four weeks after last dose of drug. * Current or recent history of clinically significant medical/psychiatric condition or laboratory abnormality that may increase risk associated with the study participation or drug administration. * Have a history of any lymphoproliferative disorder, lymphoma, leukemia, history of disseminated herpes zoster or disseminated herpes simplex, or a recurrent localized, dermatomal herpes zoster. * Have a history of infection requiring parenteral or oral or topical antimicrobial therapy within 2 weeks prior to Baseline. * Vaccinated with live/attenuated live vaccine within 6 weeks prior to Baseline. * Previously participated in study of oral/topical ruxolitinib or tofacitinib (tofacitinib, CP-690,550, formerly tasocitinib) unless confirmed to have been randomized to and treated with placebo or placebo topical formulation (vehicle) only. * Received a prohibited concomitant medication within 7 days or 5 half-lives (whichever is longer) prior to Baseline. * Have participated in other studies within 4 weeks or 5 half-lives (whichever is longer) prior to Visit 1 (Baseline/Day 1). Subjects cannot participate in studies of other investigational or experimental therapies or procedures at any time during their participation in this study. * Subjects who are investigational site staff members or relatives of those site staff members or subjects who are Sponsor employees directly involved in the conduct of the trial. * In the opinion of the investigator or Sponsor, the subject is inappropriate for entry into this study, or unwilling/unable to comply with study procedures and lifestyle guidelines. * Screening laboratory abnormalities * CYP Inhibitor Exclusion: Subjects taking potent CYP3A4 inhibitors or fluconazole within 2 weeks or 5 half-lives, whichever is longer, before the baseline visit.