Efficacy of Probiotic ES1 for the Treatment of Non-Celiac Gluten Sensitivity

Inclusion Criteria: * Age: 18-65 * Male or non-pregnant, non-lactating females. * Documented or self-diagnosed gluten sensitivity that is well-controlled. * Negative celiac serology to eliminate Celiac Disease at screening. * Written informed consent prior to any screening procedure. * Ability and willingness to comply with study requirements. * Adherence to a gluten-free diet during period of the study and 1 week prior to the first dose. * BMI \< 35 kg/m2. Exclusion Criteria: * History of diagnosis of Celiac Disease. * Positive pregnancy test at screening. * Positive HIV, Hepatitis, or Tuberculosis infection. * History of substance abuse within last 5 years. * Alcohol consumption of \> 2 standard drink equivalents per day. * Recent myocardial infarction within past 3 months, recent stroke within past 12 months, recent abdominal surgery within past 12 months, history of any malignancies and/or active treatment for a psychiatric disorder. * Use of systemic biologics within 6 months of the study. * Use of oral probiotics within 2 weeks of the study. * Use of NSAIDS or aspirin within 7 days of the study. * Use of immunosuppressants within 30 days of the study. * Family history (first degree relative) of Celiac Disease. * Received an investigational product within 1 month of study. * History of digestive enzyme deficiencies. * History of severe reactions to low doses of gluten/accidental exposure to gluten. * History of wheat allergy (positive reactions to the skin-prick test or the IgE blood test). * History of lactose, milk protein and/or FODMAP allergies. * Subjects who have an immune-compromised condition.