Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated. On the other hand, the dramatic increase in gonadotropin level didn't drew much attention when talking about the increased risk of cardiovascular disease during menopausal transition. This study aim to investigate the association between gonadal hormone, gonadotropin and long-term cardiovascular events.
Study Type
OBSERVATIONAL
Enrollment
8,000
Shandong Provincial Hospital
Jinan, Shandong, China
Rate of first cardiovascular disorder events
Total incidence rate from cardiovascular disorder over a given period of time
Time frame: Measured after 10 years of follow-up
Cardiovascular disease mortality
Total deaths from cardiovascular disease over a given period of time
Time frame: Measured after 10 years of follow-up
All-cause mortality
Total deaths from all causes over a given period of time
Time frame: Measured after 10 years of follow-up
Change in serum lipid levels
Include triglycerides、cholesterol、 low density lipoprotein cholesterol、 high density lipoprotein cholesterol.
Time frame: Measured at baseline, and every 2 years during the 10-year follow-up period
Change in thickness of blood vessel wall
The mean carotid Intima media thickness showed the early risk of atherosclerotic cardiovascular diseasean. the subclinical atherosclerosis was defined as the mean carotid Intima media thickness ≥0.78mm.
Time frame: Measured at baseline, and every 2 years during the 10-year follow-up period
Number of participants that diagnosed with metabolic syndrome
Metabolic syndrome refers to the pathological state in which protein, fat, carbohydrate and other substances in human body have metabolic disorders. It is a group of complex metabolic disorders and a risk factor leading to cardiovascular and cerebrovascular diseases of diabetes.
Time frame: Measured at baseline, and every 2 years during the 10-year follow-up period
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Number of participants that diagnosed with non-alcoholic fatty liver disease
A clinicopathological syndrome characterized by excessive deposition of fat in liver cells due to alcohol and other clearly damaging factors is excluded
Time frame: Measured at baseline, and every 2 years during the 10-year follow-up period