Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)

Insel Gruppe AG, University Hospital Bern440 enrolled

Overview

Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases

Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.

Study Type

OBSERVATIONAL

Enrollment

440

Conditions

Retinal Disease

Interventions

optical coherence tomography angiographyDEVICE

Imaging with optical coherence tomography angiography

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: Patients from the Department of Ophthalmology, University Hospital Bern requiring conventional imaging for eye disease and willing to sign informed consent Patients of 18 years or older Exclusion criteria: Patients not willing or able to sign informed consent Patients younger than 18 years Patients with epilepsy Patients having had photodynamic therapy within the last 48 hours prior to imaging with OCTA

Locations (1)

Inselspital Bern, Department of Ophthalmology

Bern, Switzerland

Outcomes

Primary Outcomes

Evaluation of the sensitivity and specificity of OCTA

The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography.

Time frame: 2 years

Secondary Outcomes

Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA

Time frame: 2 years

OCTA and Fundus color photographs

Evaluation whether pathological changes seen in OCT or color fundus photography correlate with changes seen in OCTA

Time frame: 2 years

Subgroup analysis

Subgroup analysis will be performed with patients suffering from diabetic retinopathy, artery occlusion, carotid stenosis, retinal detachment, vein occlusion, age related macular degeneration, retinal changes from arterial hypertension, retinal macroaneurysms and uveitis.

Time frame: 2 years

Data from ClinicalTrials.gov

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