Refeeding is an extracorporeal stool transport from the proximal stoma end to the distal end of stoma. Refeeding may be beneficial in preventing malabsorption, electrolyte imbalance, cholestasis and atrophy of the distal intestine. Investigators are focused on evaluating the efficacy and safety of the practice of refeeding in preterm infants with enterostomy. Clinical data including weight gain, total parenteral nutrition (TPN) usage, and other laboratory findings will be collected. Serial citrulline levels during refeeding procedure and pathologic specimens of bowel (at the time of stoma closure) will be collected for evaluating bowel adaptation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
20
when amount of feeding reach to 120mL/kg a day,
Seoul National University Hospital
Seoul, South Korea
The change of citrulline level during the study period
4 time points: at the time of full enteral feeding (\>120 cc/kg/day), 4 weeks later after full enteral feeding, at the time of stoma closure operation, 12 weeks later after closure operation
Time frame: up to 6 months of corrected age
The pathologic findings after refeeding procedure
villus height, crypt depth, mucosal thickening of pathologic specimens at the time of stoma closure operation
Time frame: up to 8 weeks of corrected age
the number of days on parenteral nutrition
the day of discontinuation of intravenous protein supplements
Time frame: up to 8 weeks of corrected age
The weight gain
differences in the admission weight Z-scores and end of study weight Z-scores
Time frame: up to 6 months of corrected age
Adverse events during refeeding procedure
bowel prolapse, enteral hemorrhage, abdominal distension, infection related stoma
Time frame: up to 8 weeks of corrected age
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